On February 24, 2005, after this article had been submitted for publication, the data and safety monitoring board indicated that the main reasons for its recommendation were interim analyses showing a trend toward more cardiovascular events in the first 10 days after randomization among patients assigned to cardiac resynchronization than among those assigned to medical therapy alone and a trend toward a favorable effect of resynchronization on long term mortality that they thought might fail to reach significance by the time of the planned closure date lasix without a rx